The cardiac Troponin I (Thr143) Antibody from Bioss Inc. is a Rabbit Polyclonal antibody to TNNI3. This antibody recognizes Human, Mouse, and Rat antigen. The cardiac Troponin I (Thr143) Antibody has been validated for the following applications: Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq]